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Defective or insufficient mitochondrial function at the cellular level is thought to impact whole-body metabolic homeostasis

Conversely, in chronic metabolic diseases such as obesity and type 2 diabetes, the body is typically in a state of nutritional overload, with BCAA circulating levels already elevated

Acknowledgements This review was supported by the National Natural Science Foundation of China (82373039) and the University-Industry Collaboration Program (New Drug Targets and New Molecule Discovery and Technology 8210040001, 2020-019)

In these cases, supplementation may be considered under professional guidance